Agreed that a large piece of artwork would be great. Perhaps even a triptych (picture/painting that is in hung in three adjacent panels) or mirror(s)?
Also consider a decorative element like a 3D sculpture. I've attached some images of ways to hang artwork over a bed - not necessarily the right colors, but just to give you an idea. Good luck!
WALLAUER'S DESIGN CENTER
Talie Jane Interiors
Liz H
Lenore Frances Home Interiors